She then went on to appear in film like Pokiri (2006), Jalsa (2008), Kick (2009), and Julayi (2012), establishing herself as one of Tollywood's leading actresses. D'Cruz made her Kollywood debut earlier in 2006 with Kedi and made a comeback in Shankar's Nanban (2012). In 2012, she made her Bollywood debut with Anurag Basu's critically and commercially successful Barfi!, for which she received critical appreciation and the Filmfare Award for Best Female Debut.
D'Cruz was born in Mumbai, Maharashtra as the second child to Ronald D'Cruz and Samira. She has three siblings — older sister Farrah, younger brother Rhys and youngest sister Eileen. Her first name comes from Greek mythology, meaning Helen of Troy. While growing up, she lived in Goa for about seven years.